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Aromatic chemistry

The introduction of diverse substituents into aromatic rings is key to the construction of many modern pharmaceuticals and agrochemicals.

Our wide tool-box of technologies enables us to prepare new substituent patterns rapidly and economically. We look forward to receiving your enquiries.

Applications and Examples
Main application	Examples
Acylation	Friedel-Crafts acylation
Alkylation	Chloroalkylation Friedel-Crafts alkylation
Aromatic coupling	Transition metal catalysis, e.g. Suzuki, Negishi
Carbonylation and carboxylation
Diazonium salts	Experience in Balz-Schiemann reactions, azo coupling, reductive deamination, Sandmeyer reaction (Br, Cl, CN)
Grignard reaction	Alkyl- and aryl-Grignard reagents
Halogenation	Side chain halogenation, bromination, chlorination, iodination
Halex	Exchange of Cl & Br by F
Metal-halogen exchange	Ar-F manufacture
Nitration
Nitrosation
Nucleophilic substitution	Amination Cyanation
Sulfonylation (and chlorosulfonylation)

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